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Clay Siegall contributes enormously to the development of precision cancer medicine

One of the great problems of cancer treatment has always been the inability of cancer-fighting drugs to specifically target the tumor itself. This results in the drugs and other treatments used to fight cancer taking on the form of blunt instruments. Rather than taking a scalpel to the problem, modern chemotherapy is all too often equivalent to taking a sledgehammer to it.

The massive systemic release of chemotherapy drugs that is required to shrink tumors is tantamount to the ingestion of near-fatal amounts of poison. In fact, oncologists actively seek to pump the patient full of his much poison as they possibly can without killing them. This is not only a dangerous tightrope act, putting the patient’s life in the balance, it is also a virtually guaranteed means of creating lasting side effects, including peripheral neuropathy, so-called chemo brain or dementia secondary to ingestion of poisonous chemotherapy and a wide range of other, lasting neurological deficits.

The challenge in cancer research has, therefore, been to develop a class of drugs that no longer requires the systemic release of large amounts of highly toxic poison into the bloodstream. One solution to this problem is what is broadly referred to as targeted cancer therapy, a subcategory of precision medicine. While there are many different approaches to the development of targeted cancer therapies, one area has been the class of drugs known as antibody drug conjugates.

These drugs were largely developed, in the mid-90s, by one man and his team of researchers at pharmaceutical giant Bristol-Myers Squibb. Clay Siegall had long been one of the star researchers in the cancer industry, working for more than 15 years at the National Cancer Institute and a number of other large pharmaceutical companies. He began developing antibody drug conjugates while still add Bristol-Myers Squibb, but later founded his own company, Seattle Genetics, which eventually went on to developed the first FDA-approved antibody drug conjugate, called ADCetris. Today, ADCetris is one of the few antibody drug conjugates approved for multiple indications by the FDA. The drug has saved thousands of lives and has made millions of dollars in profits for Seattle Genetics.

Celebrating the Life of A.R. Gurney

The prolific playwright, screenwriter, and novelist, A.R. Gurney passed away recently at the noble age of 86 years old. Gurney was a native of New York City and is survived by his wife of 60 years, Molly Gurney. Mr. Gurney also leaves behind four children and eight beloved grandchildren. The New York Times, a paper that has been involved in the career of A.R. Gurney for decades since his initial release of his classic play, The Cocktail Hour, has recently published a piece that relays the events of Gurney’s eventful life – a life that was filled to the brim with creative ingenuity, passionate storytelling, and utter talent.

 

Gurney was born in Buffalo, New York, the middle child of A.R. Gurney, Sr. and Marion Spaulding. After graduating from Williams College in 1952, Gurney attend Yale School of Drama for four years. He then began to work as a humanities professor at MIT. Gurney maintained a stead career as a professor for 20 years before he was able to write plays full time. His first successful play was The Dining Room, a play released in 1981. Following the commercial success of this play, Gurney began a career of full-time play and script writing. His stories often explored the anxieties of upper class, white, anglo saxon life in the Northeast. Having being brought up among this group of people, Gurney had a unique outlook on the lives of these people and included characters based off people he had known in New York in virtually every play he every wrote.

 

Following the release of his first successful play, which explored themes of culture, traditional values, infidelity, senescence, and denial, A. R. Gurney went on to produce over 50 unique plays, 4 novels, and 10 screen plays. The writer is know remembered for his extraordinary contribution to American theatre, his courageous style of writing that reflecting the ideals of an entire generation, and his love for the arts.

 

Victor Lewis-Smith Wants To Create A Dalek Documentary

Victor Lewis-Smith, the esteemed BBC documentary filmmaker, is working on an interesting new project. Titled The Undiscovered Daleks, the crowdfunding project hopes to tell the secret history of The Daleks.

 

The Daleks have served as Doctor Who’s main nemeses since they debuted in 1963. The frightening and ominous metallic beings took the United Kingdom by storm. The Daleks returned time and time again over the decades. They never beat The Doctor, but they do create enormous havoc.

 

Terry Nation created the villainous beings and he wrote many of the most memorable episodes. Serious fans of the series surely watched all the Dalek episodes. Not everyone knows the full story behind the creation of The Daleks. The documentary should reveal the true tale about how these iconic science-fiction villains came to be.

 

Ironically, although Lewis-Smith has done a significant amount of work for the BBC for years, the network consistently turned down his pitches for a Dalek documentary. Lewis-Smith is going forward with his plans as evidenced by the crowdfunding campaign. Theatrical distribution is a possibility, but limited engagements won’t be the only venues in which to see the project. If it is completed, the documentary should end up being a hit on DVD, Blu-ray, and online streaming. The Doctor Who series has legions of loyal fans who would love to see the documentary on the Daleks. Does this not make the BBC’s decision to turn down the pitches for the project more quizzical?

 

Maybe not producing the documentary for BBC could work out for the best. Perhaps Lewis-Smith will be afforded more freedom to create a documentary closer to his personal vision.

 

The director’s labor of love might turn out to be one of the more intriguing sci-fi documentaries every produced.

 

Why Anthony Petrello is Among the Renowned Business Executives in the World

Anthony Petrello is one of the top corporate executives in the world. He is the man behind the steering of the Hamilton, Bermuda-based Nabors Industries Ltd, as the Chairperson of the board, CEO and president. Since joining the company, Petrello has done a commendable job of leading the company to become the largest natural gas and geothermal drilling company in the world.

Work and Education

Away from business, Petrello holds an excellent academic record comprising of an MS and BS degree in mathematics from Yale University. He also holds a Juris Doctor from the prestigious Harvard Law School. Anthony Petrello embarked on his career journey in 1979 by joining the Baker & McKenzie law firm. He served as the managing partner of the firm’s NY office from 1986 to 1991.

Anthony’s career breakthrough came in 1991 when he joined Nabors Industries as the company’s chief operating officer. Later in 1992, he ascended to become the president of Nabors. From 2003 to June 2012, Tony was the deputy chairperson of Nabors Industries. Anthony Petrello appointed to serve as the CEO of Nabors in 2011 before becoming the chairperson of the board in 2012

Compensation as of FY 2015

As the head of the largest geothermal and natural gas drilling contractor, Anthony Petrello receives  significant compensation package. In 2015, his total compensation was $27,512,939. This amount comprised of $7,727,000 as bonus, $16,863,656 as stock, $1,580,077 as salary and $1,342,206 as other kinds of compensation.

Membership and Other Roles

Apart from his service to Nabors Industries Ltd, Anthony Petrello also serves other companies and entities. As such, he has been the director of Stewart & Stevenson LLC since 2012. Tony is also the director of Texas Children’s Hospital. He is a renowned advocate for clinical programs and research aimed at addressing the needs of children with neurological disorders. Additionally, Tony serves a member of the board of trustees of the Texas Children’s Hospital.

About Nabors Industries

Nabors not only owns but also operates the globe’s largest land-drilling fleet of rigs. As such, it is the top provider of offshore drilling rigs across international markets and the United States. Furthermore, has a reputation for providing innovative technologies, directional drilling services and performance tools across the globe’s significant gas and oil markets to know more: http://fuelfix.com/blog/tag/anthony-petrello/ click here.

‘Black Mirror’ Book Series to be Edited by Charlie Brooker

Black Mirror, the popular TV and Netflix series known for focusing on high-tech futuristic themes, is about to get a very low-tech spin. Charlie Brooker, the English satirist responsible for the writing and concepts behind the sci-fi show, recently announced to BBC that he will be the editor of three anthology volumes to be published in what he calls a “high-tech ‘paper’ format.”

 

Brooker has been pushing the envelope with his satirical writing since the early ’90s, and made the move to television in the early ’00s with non-fiction work about technology and television. His fascination with modern technology, especially the personal kind that most people use daily in their own homes and lives, grew along with the technology itself and culminated in the 2011 debut of Black Mirror. While each episode has its own unique characters, setting and reality, a connecting thread of dystopian euphoria winds its way throughout the series, exploring the ways personal technology affects our world both for better and worse. As Brooker himself put it to The Guardian, “If technology is a drug – and it does feel like a drug – then what, precisely, are the side-effects? This area – between delight and discomfort – is where Black Mirror, my new drama series, is set.” He goes on to explain that the title itself refers to the shiny dark screens of televisions, computers and smartphones, reflecting humanity wherever we go.

 

The new book series, set to be published in February of 2018, will require no black mirror to enjoy and will consist of novellas written by various authors and edited by Brooker. The satirist seems excited about this lateral move in format, remarking drolly that “Apparently, you just have to glance at some sort of ink code printed on paper and images and sounds magically appear in your head, enacting the story. Sounds far-fetched to me, but we’ll see.”

 

Tom Green Returns to Comedy

Canadian comedian Tom Green was a regular fixture of late ’90s and early ’00s pop culture. Green enjoyed a brief marriage to Drew Barrymore, had his name immortalized by rapper Eminem, was fired by the 45th president of the United States and is responsible for the cinematic abomination known as “Freddy Got Fingered.” Green also gained fame for focusing an episode of his MTV television show on his testicular cancer. While all of these are tales of the Tom Green from the past, Green is gearing up for a new comedy tour throughout the United Kingdom.

 

Green commented that the persona he used for his old antics took its toll on him and he eventually burnt out on being on television. Green winces at descriptions of his old routine as shock or gross-out humor. While he has maintained a limited presence through “Tom Green’s House Tonight,” the online talk show pales in comparison to his return to traditional stand-up comedy. Green’s act covers the hazards of technology, social media, struggling with cancer and being childless at age 45.

 

Beyond his resurgence as a stand-up comedian, Green seems to be finally getting some degree of respect. Eric Andre, a comedian involved with Cartoon Network’s Adult Swim program block, attributes Green’s off-the-wall antics as inspiration for his own career. At least one website has described Green as the progenitor of internet trolling.

 

Green sees stand-up comedy as his future. He jokes that twenty years from now, when he’s still performing for audiences, he hopes some people will be interested about his material from his 20s but will have to go looking around for video evidence rather than being consciously aware of it. Beyond his work with MTV and making Freddy Got Fingered, Green also stars in “Road Trip,” “Charlie’s Angels,” “Stealing Harvard” and “Shred.” Green’s guest host appearance on “The Tonight Show” earned him his own late-night program on MTV, branded as “The New Tom Green Show.”

 

How Eric Pulier Succeeded in Technology

Eric Pulier is a name not known by everyone, but known by those in the tech field who want to follow in his entrepreneurial footsteps. Eric Pulier is a technologist, an author, a speaker, and a philanthropist. He has played a part in founding or funding over 15 different companies and his work as a philanthropist will live on for generations to come in the lives that he has helped to touch. Learning from Eric Pulier probably isn’t such a bad idea. We dug into his day to day day habits in order to illuminate some aspects of his life that make him so successful.

 

So, right now Eric Pulier is absorbed in his focus on vAtomic Systems. This company saw the converging market trends of mobile technology, like mobile games, and digital micro transactions. Pulier decided to get in on this early in order to establish himself as one of the biggest players in the explosive market. Pulier cites companies like Google Maps and Uber as primary influences for this early decision.

 

Looking past the company he is currently focused on we can analyze Pulier’s day to day life and take from it a certain amount of beneficial knowledge. Pulier is the father of four children so suffice to say his mornings are pretty stacked up with things to do. That is why Pulier focuses on getting a solid night of rest before getting up early, well in advance of his children. During this time he focuses on reading and centering himself before the storm of activity that comes with four very active and hyper children. After he bundles them off to school his focus goes back to work.

 

Pulier is meticulous in his approach to note taking and this has given him the ability to really tackle some great concepts. Pulier stacks up a list of projects that he wants to accomplish each day and he doesn’t rest until he accomplishes them. Along the way he remains open to new ideas and jots down notes whenever one might come along that sounds particularly promising — this is a very important step to his success.

Phil Collins Cancels London Concerts After Hotel Fall

The legendary music career of Phil Collins has continued to evolve for more than four decades, beginning with his tenure with Genesis and continuing through a strong solo career. However, the 66-year-old singer-songwriter’s health is currently on the mend after he suffered what was described as a severe gash near his eye after he fell late Wednesday night.

 

Collins arose in the middle of the night in a hotel room to use the bathroom when he fell, with his head striking a nearby chair. The injury was severe enough for him to be briefly hospitalized and forced him to postpone scheduled concerts at Royal Albert Hall in London on both June 8 and 9.

 

Collins’ staff attributed the fall to a condition that afflicts Collins known as drop foot. The health problem is a complication of back surgery that left him with problems when it came to walking.

 

The postponement of the concerts was announced by Collins’ staff on the day of the first concert, with the two performances rescheduled for November 26 and 27. His staff made an effort to convey Collins’ regret in being forced to postpone the concerts.

 

Collins recently returned to performing in concert after being away for the last decade and will continue his tour of Europe on June 11, when he performs in Cologne. Following that concert, he’ll perform in Paris before again returning to London to play Hyde Park on June 30.

 

During Collins’ time away in what he had described as a retirement, he took time to release his autobiography. The book explored the rise of Genesis and the subsequent spawning of the solo career and the toll that constant touring and fame had taken on Collins’ family life.

 

That toll had included multiple failed marriages, substance abuse issues involving alcohol and a fractured relationship with his daughter, Lily. In the latter case, Lily Collins has carved out a prominent career of her own as an actress.

 

OSI And David

Global companies, local in nature, cannot be otherwise. Any organization with branches throughout the U.S., Europe and China can’t run one-size-fits-all operations. Government regulations with cultural nuances and talent pools may all affect how any company is run. Within the food industry, such considerations also include the consumer’s taste buds.

David McDonald, the President of OSI Group, states that he and his staff are well-positioned in having a global network of the best people and resources. David McDonald OSI Group claims that having a global operation means that one may scale in size but also have local management teams both sensitive and professionally understanding of all local cultures and tastes. The power of global scale efficiency combines with local solutions.

With headquarters in Aurora, Ill., The OSI Group’s a global leader that supplies value-added protein items like sausage links or beef patties. It also supplies items like sandwiches and pizza – to top foodservice and retail brands. This privately-held corporation runs more than 50 facilities throughout 17 countries and currently employs global-efficiency, local-solution strategies to expand its operations in China.

Read more on medium.com.

OSI Group has successfully operated in China within the last 20 years; as China’s economy has grown, the company’s presence has also grown. Operating eight factories – and with two -brand new facilities on the way – The OSI Group hopes to soon become the nation’s largest poultry producer. Last September, it broke ground on new mega-plants sought for further processing in the Henan province. In the same month, it announced joint-venture agreements in Zhoukou through DOYOO Group – to form DaOSI, The OSI Group’s third fully- vertical, integrated poultry operation in that country. OSI’s China division serves clients like McDonald’s, Starbucks, Saizeriya, Papa John’s and Subway.

China’s a top focus of David for all the reasons read about every day. It only continues to rise as the biggest growing consumer market on earth and thus carries with it the power of population. That population grows more affluent as well. OSI has some great customers in China who experience tremendous growth, and David McDonald simply wishes to keep up with such customers.

Adam Milstein is Honored Alongside Other World’s Most Influential Names

Adam Milstein appeared in a list that honored the ‘200 Most Influential Do-Gooders in the World“. The list recognizes leading philanthropists and social entrepreneurs on social media. It is compiled by Richtopia, a London-based publication, in collaboration with social media ranking system, Rise.

Philanthropist business leader’s names on the list include Warren Buffett, Bill and Melinda Gates, Elon Musk, Eric Trump and Mark Zuckerberg. Politicians popular for their charity work like Bill Clinton, Hillary Clinton, Barrack Obama and Michelle Obama also appeared on the list. Influential philanthropic public figures were not left out. Examples of those featured were Oprah Winfrey, J.K Rowling, Ashton Kutcher, Elton John and Magic Johnson.

His Twitter and Facebook accounts’ influence on philanthropy gave Adam number No. 187 on the list. Adam is behind the Israeli-American Council(IAC). He is involved in the leadership of many Jewish organizations like StandWithUs, Hasbara Fellowships, The Israel On Campus Coalition, and AIPAC.

Adam was humbled to have appeared on the list alongside many influential leaders. He is grateful for his wife Gila, the IAC and all the organizations that have partnered with him to make his mission a reality.

At the Adam and Gila Foundation, Adam is focused on bringing the Jewish community closer to the Israeli culture by influencing the next generation, educating the pro-Israel Americans to advocate for the State of Israel and fostering the U.S.-Israel alliance.

 

Adam Milstein’s History

Adam is his parent’s first-born son. His father made his livelihood as a real estate developer, and his mother was a homemaker. Both his parents were both immigrants from other countries to Israeli.

In 1971, AdamMilstein joined the Israeli Defense Forces and served it during the 1973 Kippur War. After his mandatory work at the Israeli Army, he joined the Israeli Institute of Technology and attained a BS degree in Business and Economics in 1978. During his higher education years, he helped his father in running the family real estate construction and development business.

Adam is Married to Gila Elgrably. Together they have three daughters. He did an MBA at the University of Southern California, in 1983. His career in real estate started as a sales agent.